Drug Information on Zoloft (sertraline) includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid. Taking an SSRI antidepressant during pregnancy may cause serious lung problems or. The purpose of this study was to compare sertraline and paroxetine in the acute weeks of treatment with flexible doses of sertraline (titrated up to mg/day; Paroxetine/administration & dosage; Paroxetine/therapeutic use*; Serotonin. Paxil (paroxetine) is effective for treating depression and anxiety, but causes more Zoloft. Head-to-head comparisons of medication uses, side effects, ratings.